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Literature summary for 3.1.3.16 extracted from
- The scaffolding A/Tpd3 subunit and high phosphatase activity are dispensable for Cdc55 function in the Saccharomyces cerevisiae spindle checkpoint and in cytokinesis (2004), J. Biol. Chem., 279, 48598-48606.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of diverse Cdc55 mutants by random mutagenesis, analysis of their ability to interact with PP2A, overview | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | PP2A is a multifunctional enzyme, direct interaction with the adenovirus E4orf4 protein via the regulatory subunit initiation virus-induced growth arrest in yeast cells, signal transduction is mediated by Cdc55 interacting with both PP2A catalytic subunit in absence of the Tpd3 subunit and E4orf4, mechanism involving the Tpd3 yeast subunit, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
several strains | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PP2A is a multifunctional enzyme, direct interaction with the adenovirus E4orf4 protein via the regulatory subunit initiation virus-induced growth arrest in yeast cells, signal transduction is mediated by Cdc55 interacting with both PP2A catalytic subunit in absence of the Tpd3 subunit and E4orf4, mechanism involving the Tpd3 yeast subunit, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | PP2A is a multifunctional enzyme, direct interaction with the adenovirus E4orf4 protein via the regulatory subunit | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | the enzyme consists of a scaffolding A subunit, a catalytic C subunit, and one of several regulatory subunits B, B', or B'' | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PP2A | - |
Saccharomyces cerevisiae |
| protein serine/threonine phosphatase 2A | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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