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Literature summary for 3.1.3.16 extracted from

  • Zhang, X.; Ozawa, Y.; Lee, H.; Wen, Y.D.; Tan, T.H.; Wadzinski, B.E.; Seto, E.
    Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4 (2005), Genes Dev., 19, 827-839.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated histone deacetylase 3 + H2O Homo sapiens dephosphorylation at Ser424, PP4 negatively regulates the activity of histone deacetylase 3 by direct protein-protein interaction also involving the so-repressors N-CoR and SMRT histone deacetylase 3 + phosphate
-
 ?
phosphorylated histone deacetylase 3 + H2O Homo sapiens PP4 regulates histone deacetylase 3, HDAC3, activity by dephosphorylation of Ser424, and by direct protein-protein interaction of active PP4 which is complexed with HDAC3 via the N-terminus of the deacetylase, PP4 is the limiting factor and is not saturating in the complex in vivo histone deacetylase 3 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated histone deacetylase 3 + H2O dephosphorylation at Ser424, PP4 negatively regulates the activity of histone deacetylase 3 by direct protein-protein interaction also involving the so-repressors N-CoR and SMRT Homo sapiens histone deacetylase 3 + phosphate
-
 ?
phosphorylated histone deacetylase 3 + H2O PP4 regulates histone deacetylase 3, HDAC3, activity by dephosphorylation of Ser424, and by direct protein-protein interaction of active PP4 which is complexed with HDAC3 via the N-terminus of the deacetylase, PP4 is the limiting factor and is not saturating in the complex in vivo Homo sapiens histone deacetylase 3 + phosphate
-
 ?
phosphorylated histone deacetylase 3 + H2O i.e. HDAC3, a class I histone deacetylase, dephosphorylation at Ser424 of the protein kinase CK2 phosphoacceptor site Homo sapiens histone deacetylase 3 + phosphate
-
 ?
phosphorylated histone deacetylase 3 + H2O PP4 dephosphorylates Ser424 Homo sapiens histone deacetylase 3 + phosphate
-
 ?
RRAS(P)VA + H2O synthetic substrate Homo sapiens RRASVA + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Pp4
-
 Homo sapiens
protein serine/threonine phosphatase 4
-
 Homo sapiens
serine/threonine protein phosphatase 4
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens