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Literature summary for 3.1.3.16 extracted from

  • Haneda, M.; Kojima, E.; Nishikimi, A.; Hasegawa, T.; Nakashima, I.; Isobe, K.
    Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53 (2004), FEBS Lett., 567, 171-174.
    View publication on PubMed
Search for more literature for 3.1.3.16

Inhibitors

Inhibitors Comment Organism Structure
additional information DNA damage 34, i.e. gADD34, and growth arrest disturb the binding of PP1 to p53 Mus musculus
okadaic acid
-
 Homo sapiens
okadaic acid
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Mus musculus
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated p53 + H2O Mus musculus dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function p53 + phosphate
-
 ?
phosphorylated p53 + H2O Homo sapiens dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function p53 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-
HEK-293 cell
-
 Homo sapiens
-
MEF cell embryonic fibroblast cell line from GADD34-deficient mice and from wild-type mice Mus musculus
-
WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated p53 + H2O dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function Mus musculus p53 + phosphate
-
 ?
phosphorylated p53 + H2O dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function Homo sapiens p53 + phosphate
-
 ?
phosphorylated p53 + H2O dephosphorylation of Ser15 by PP1, no activity with PP2A Mus musculus p53 + phosphate
-
 ?
phosphorylated p53 + H2O dephosphorylation of Ser15 by PP1, no activity with PP2A Homo sapiens p53 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP1
-
 Mus musculus
PP1
-
 Homo sapiens
PP2A
-
 Mus musculus
PP2A
-
 Homo sapiens
protein phosphatase 1
-
 Mus musculus
protein phosphatase 1
-
 Homo sapiens
protein phosphatase 2A
-
 Mus musculus
protein phosphatase 2A
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens