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Literature summary for 3.1.3.16 extracted from

  • Hall, D.D.; Feekes, J.A.; Arachchige Don, A.S.; Shi, M.; Hamid, J.; Chen, L.; Strack, S.; Zamponi, G.W.; Horne, M.C.; Hell, J.W.
    Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation (2006), Biochemistry, 45, 3448-3459.
    View publication on PubMed
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged regulatory subunit delta in Escherichia coli Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin
-
 Oryctolagus cuniculus
cypermethrin
-
 Oryctolagus cuniculus
fostriecin
-
 Oryctolagus cuniculus
microcystin
-
 Oryctolagus cuniculus
okadaic acid
-
 Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated Cav1.2 + H2O Oryctolagus cuniculus binding of PP2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation Cav1.2 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus Q28653 regulatory subunit delta, isozyme PP2Adelta; isozyme PP2Adelta
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-tagged regulatory subunit delta from Escherichia coli by glutathione affinity chromatography Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated Cav1.2 + H2O binding of PP2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation Oryctolagus cuniculus Cav1.2 + phosphate
-
 ?
phosphorylated Cav1.2 + H2O binding of PP2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation, interaction study, overview Oryctolagus cuniculus Cav1.2 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PP2A
-
 Oryctolagus cuniculus
protein phosphatase 2A
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Oryctolagus cuniculus