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Literature summary for 3.1.3.16 extracted from
- Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole (2005), Biochem. J., 385, 45-56.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| arachidonic acid | causes loss of heat shock protein interaction and increases Ppp5 activity, the effect of arachidonic acid on Ppp5 is increased by Rho kinase inhibitor Y27632, which is not affecting alone | Homo sapiens |  |
| HSP70 | heat shock protein, activation of Ppp5 by dissociation from Hsp70 | Homo sapiens | |
| Hsp90 | heat shock protein, activation of Ppp5 by dissociation from Hsp90 | Homo sapiens | |
| additional information | activation of Ppp involves translocation from the nucleus to the cytoplasm, activation mechanism, overview | Homo sapiens | |
| nocodazole | causes loss of heat shock protein interaction and increases Ppp5 activity | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of FLAG-tagged Ppp5 in HEK-293 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | activation of Ppp involves translocation from the nucleus to the cytoplasm | Homo sapiens | 5737 | - |
| nucleus | activation of Ppp involves translocation from the nucleus to the cytoplasm | Homo sapiens | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
x * 45000-50000 + x * 130000, recombinant Ppp5, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant FLAG-tagged and/or HA-tagged Ppp5 from HEK-293 cells | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000-50000 + x * 130000, recombinant Ppp5, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ppp5 | - |
Homo sapiens |
| protein phosphatase 5 | - |
Homo sapiens |
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