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Literature summary for 3.1.3.16 extracted from
- Purification and characterization of a novel xylulose 5-phosphate-activated protein phosphatase catalyzing dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase (1995), J. Biol. Chem., 270, 26341-26346.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Xylulose 5-phosphate | activation of a heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| okadaic acid | inhibition of heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase is not dependent on Mg2+, Ca2+, or Mn2+ | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
1 * 65000 + 1 * 52000 + 1 * 36000, heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus |
| 52000 | - |
1 * 65000 + 1 * 52000 + 1 * 36000, heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus |
| 65000 | - |
1 * 65000 + 1 * 52000 + 1 * 36000, heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus |
| 150000 | - |
heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase, gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + H2O | Rattus norvegicus | heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + H2O | - |
Rattus norvegicus | ? + phosphate | - |
? | |
| fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + H2O | heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus | fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + phosphate | - |
? | |
| phosphoproteins + H2O | - |
Rattus norvegicus | proteins + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 1 * 65000 + 1 * 52000 + 1 * 36000, heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase | Rattus norvegicus |
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