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Literature summary for 3.1.3.16 extracted from
- The chemical mechanism of calcineurin: A model for phosphotyrosyl protein phosphatases (1987), Adv. Protein Phosphatases, 4, 95-125.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pentafluorophenol | - |
Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.7 | - |
Tetrafluorotyrosine phosphate | - |
Bos taurus | |
| 4.2 | - |
fluorotyrosine phosphate | - |
Bos taurus | |
| 6.2 | - |
tyrosine phosphate | - |
Bos taurus | |
| 10.1 | - |
p-nitrophenyl phosphate | - |
Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Bos taurus | |
| Mn2+ | activation | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | 90000 | phosphatase 2B, i.e. calcineurin, sedimentation equilibrium centrifugation | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate | mechanism of calcineurin catalysed reaction | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fluorotyrosine phosphate + H2O | - |
Bos taurus | fluorotyrosine + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Bos taurus | p-nitrophenol + phosphate | - |
? | |
| phospho-D,L-tyrosine + H2O | - |
Bos taurus | D,L-tyrosine + phosphate | - |
? | |
| phospho-L-tyrosine + H2O | - |
Bos taurus | L-tyrosine + phosphate | - |
? | |
| phosphoproteins + H2O | comparison of amino acid sequence of substrates at phosphorylated sites | Bos taurus | proteins + phosphate | - |
? | |
| tetrafluorotyrosine phosphate + H2O | - |
Bos taurus | tetrafluorotyrosine + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | calcineurin B: 19200, Ca2+ binding, 35% homology with bovine brain calmodulin | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Bos taurus |
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Release 2023.1 (January 2023)
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