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Literature summary for 3.1.3.12 extracted from
- Biochemical characterization and ligand-binding properties of trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis (2013), Acta Biochim. Biophys. Sin., 45, 837-844.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Mycobacterium tuberculosis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Mycobacterium tuberculosis |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46228 | - |
x * 46228, MALDI-TOF mass spectrometry | Mycobacterium tuberculosis |
| 46236 | - |
x * 46236, calculated from amino acid sequence | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trehalose 6-phosphate + H2O | Mycobacterium tuberculosis | - |
trehalose + phosphate | - |
? | |
| trehalose 6-phosphate + H2O | Mycobacterium tuberculosis ATCC 25618 | - |
trehalose + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis ATCC 25618 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA affinity column chromatography and S200 gel filtration | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trehalose 6-phosphate + H2O | - |
Mycobacterium tuberculosis | trehalose + phosphate | - |
? | |
| trehalose 6-phosphate + H2O | - |
Mycobacterium tuberculosis ATCC 25618 | trehalose + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 46228, MALDI-TOF mass spectrometry | Mycobacterium tuberculosis |
| ? | x * 46236, calculated from amino acid sequence | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPP | - |
Mycobacterium tuberculosis |
| trehalose-6-phosphate phosphatase | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | an essential enzyme for growth | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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