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Literature summary for 3.1.3.12 extracted from

  • Van Dijck, P.; De Rop, L.; Szlufcik, K.; Van Ael, E.; Thevelein, J.M.
    Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation (2002), Infect. Immun., 70, 1772-1782.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.12

Application

Application Comment Organism
medicine enzyme may serve as a potential target for antifungal drugs Candida albicans

Cloned(Commentary)

Cloned (Comment) Organism
commentary Saccharomyces cerevisiae
construction of homozygous and heterozygous deletion mutants, the homozygous deletion mutants has little or no enzyme activity, the complete inactivation of enzyme results in 50fold hyperaccumulation of trehalose 6-phosphate, thermosensitivity, and rapid death of the cells after a few hours at 44°C Candida albicans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
973000
-
 calculated from amino acid sequence Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trehalose 6-phosphate + H2O Candida albicans
-
 trehalose + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Candida albicans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trehalose 6-phosphate + H2O
-
 Candida albicans trehalose + phosphate
-
 ?