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Literature summary for 3.1.3.11 extracted from

  • Nie, Q.; Miao, H.; Miao, S.; Zhou, H.; Zhang, Y.; Zhang, W.; Mai, K.
    Effects of dietary glucose and dextrin on activity and gene expression of glucokinase and fructose-1,6-bisphosphatase in liver of turbot Scophthalmus maximus (2015), Fish Physiol. Biochem., 41, 819-832 .
    View publication on PubMed
Search for more literature for 3.1.3.11

Cloned(Commentary)

Cloned (Comment) Organism
cloned by rapid amplification of cDNA end technique Scophthalmus maximus
gene SMAX5B_013904, enzyme is cloned from liver, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, quantitative RT-PCR enzyme expression analysis Scophthalmus maximus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O Scophthalmus maximus
-
 D-fructose 6-phosphate + phosphate
-
 ?
D-fructose 1,6-bisphosphate + H2O Scophthalmus maximus one of the key enzymes in gluconeogenesis D-fructose 6-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Scophthalmus maximus T1W0T2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low enzyme expression level Scophthalmus maximus
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brain intermediate activity Scophthalmus maximus
-
gill very low enzyme expression level Scophthalmus maximus
-
heart low activity Scophthalmus maximus
-
heart very low enzyme expression level Scophthalmus maximus
-
intestine low activity Scophthalmus maximus
-
intestine low enzyme expression level Scophthalmus maximus
-
kidney low enzyme expression level Scophthalmus maximus
-
kidney intermediate activity Scophthalmus maximus
-
liver high enzyme expression level Scophthalmus maximus
-
liver the highest expression of glucokinase is found in liver, followed by muscle Scophthalmus maximus
-
additional information expression of FBPase is higher in liver than heart and gill, tissue distribution of FBPase mRNA, overview Scophthalmus maximus
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muscle dorsal white muscle, moderate enzyme expression level Scophthalmus maximus
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muscle the highest expression of glucokinase is found in liver, followed by muscle Scophthalmus maximus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Scophthalmus maximus D-fructose 6-phosphate + phosphate
-
 ?
D-fructose 1,6-bisphosphate + H2O one of the key enzymes in gluconeogenesis Scophthalmus maximus D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
FBPase
-
 Scophthalmus maximus
fructose-1,6-bisphosphatase
-
 Scophthalmus maximus
SMAX5B_013904
-
 Scophthalmus maximus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
 annealing temperature Scophthalmus maximus

Expression

Organism Comment Expression
Scophthalmus maximus no significant difference in FBPase mRNA levels between all dietary treatments, overview additional information
Scophthalmus maximus activated by dietary carbohydrates up

General Information

General Information Comment Organism
metabolism the enzyme is part of the carbohydrate metabolism in the carnivorous fish species. Fructose-1,6-bisphosphatase (FBPase) plays a crucial role in glucose metabolism, together with glucokinase. Feeding with dietary carbohydrates causes no significant differences in FBPase activity and mRNA expression in the glucose as well as dextrin group, while both hepatic glucokinase activity and mRNA expression are highly induced in turbot. The increased hepatic glucokinase activity and gene expression indicates that the first step of glycolysis is activated in turbot by dietary carbohydrates Scophthalmus maximus
metabolism one of the key enzymes in gluconeogenesis Scophthalmus maximus
physiological function fructose-1,6-bisphosphatase (FBPase) plays a crucial role in glucose metabolism, together with glucokinase Scophthalmus maximus