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Literature summary for 3.1.3.11 extracted from

  • Li, D.; Han, X.; Tu, Q.; Feng, L.; Wu, D.; Sun, Y.; Chen, H.; Li, Y.; Ren, Y.; Wan, J.
    Structure-based design and synthesis of novel dual-target inhibitors against cyanobacterial fructose-1,6-bisphosphate aldolase and fructose-1,6-bisphosphatase (2013), J. Agric. Food Chem., 61, 7453-7461.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,4-dihydroxy-N'-[(E)-[4-oxo-6-(propan-2-yl)-4H-chromen-3-yl]methylidene]benzohydrazide compound potently inhibits both fructose-1,6-bisphoshate aldolase and fructose-1,6-bisphosphatase with IC50 values below 30 microM Synechocystis sp.
N'-[(E)-(6-ethyl-4-oxo-4H-chromen-3-yl)methylidene]-3,4-dihydroxybenzohydrazide compound potently inhibits both fructose-1,6-bisphoshate aldolase and fructose-1,6-bisphosphatase with IC50 values below 30 microM Synechocystis sp.
N'-[(E)-(6-tert-butyl-4-oxo-4H-chromen-3-yl)methylidene]-3,4-dihydroxybenzohydrazide compound potently inhibits both fructose-1,6-bisphoshate aldolase and fructose-1,6-bisphosphatase with IC50 values below 30 microM Synechocystis sp.

Organism

Organism UniProt Comment Textmining
Synechocystis sp. P73922
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-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0141
-
pH 7.5, temperature not specified in the publication Synechocystis sp. N'-[(E)-(6-tert-butyl-4-oxo-4H-chromen-3-yl)methylidene]-3,4-dihydroxybenzohydrazide
0.0147
-
pH 7.5, temperature not specified in the publication Synechocystis sp. 3,4-dihydroxy-N'-[(E)-[4-oxo-6-(propan-2-yl)-4H-chromen-3-yl]methylidene]benzohydrazide
0.019
-
pH 7.5, temperature not specified in the publication Synechocystis sp. N'-[(E)-(6-ethyl-4-oxo-4H-chromen-3-yl)methylidene]-3,4-dihydroxybenzohydrazide