Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | AMP, ADP or glucose have no effect on enzyme activity | Archaea | |
additional information | AMP, ADP or glucose have no effect on enzyme activity | Cenarchaeum symbiosum | |
additional information | AMP, ADP or glucose have no effect on enzyme activity | Ignicoccus hospitalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | AMP, ADP or glucose have no effect on enzyme activity | Archaea | |
additional information | AMP, ADP or glucose have no effect on enzyme activity | Cenarchaeum symbiosum | |
additional information | AMP, ADP or glucose have no effect on enzyme activity | Ignicoccus hospitalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
D-fructose 1,6-bisphosphate | pH not specified in the publication, 40°C | Cenarchaeum symbiosum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose 1,6-bisphosphate + H2O | Archaea | - |
D-fructose 6-phosphate + phosphate | - |
? | |
D-fructose 1,6-bisphosphate + H2O | Cenarchaeum symbiosum | - |
D-fructose 6-phosphate + phosphate | - |
? | |
D-fructose 1,6-bisphosphate + H2O | Ignicoccus hospitalis | - |
D-fructose 6-phosphate + phosphate | - |
? | |
additional information | Archaea | bifunctional fructose 1,6-bisphosphate, FBP, aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity | ? | - |
? | |
additional information | Cenarchaeum symbiosum | bifunctional fructose 1,6-bisphosphate, FBP, aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity | ? | - |
? | |
additional information | Ignicoccus hospitalis | bifunctional fructose 1,6-bisphosphate, FBP, aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Archaea | - |
- |
- |
Cenarchaeum symbiosum | - |
- |
- |
Ignicoccus hospitalis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose 1,6-bisphosphate + H2O | - |
Archaea | D-fructose 6-phosphate + phosphate | - |
? | |
D-fructose 1,6-bisphosphate + H2O | - |
Cenarchaeum symbiosum | D-fructose 6-phosphate + phosphate | - |
? | |
D-fructose 1,6-bisphosphate + H2O | - |
Ignicoccus hospitalis | D-fructose 6-phosphate + phosphate | - |
? | |
additional information | bifunctional fructose 1,6-bisphosphate, FBP, aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity | Archaea | ? | - |
? | |
additional information | bifunctional fructose 1,6-bisphosphate, FBP, aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity | Cenarchaeum symbiosum | ? | - |
? | |
additional information | bifunctional fructose 1,6-bisphosphate, FBP, aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity | Ignicoccus hospitalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
archaeal FBP aldolase/phosphatase | - |
Archaea |
archaeal FBP aldolase/phosphatase | - |
Cenarchaeum symbiosum |
archaeal FBP aldolase/phosphatase | - |
Ignicoccus hospitalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
assay at | Cenarchaeum symbiosum |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
the archaeal FBP aldolase/phosphatases are highly thermostable | Archaea |
70 | - |
heat-stable for up to 1 h | Cenarchaeum symbiosum |
82 | - |
heat-stable, half-life is 20 min | Ignicoccus hospitalis |
General Information | Comment | Organism |
---|---|---|
evolution | virtually all archaeal groups as well as the deeply branching bacterial lineages contain the bifunctional D-fructose 1,6-bisphosphate aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity. This enzyme is missing in most other bacteria and in eukaryota. Phylogenetic analysis, overview | Archaea |
evolution | virtually all archaeal groups as well as the deeply branching bacterial lineages contain the bifunctional D-fructose 1,6-bisphosphate aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity. This enzyme is missing in most other bacteria and in eukaryota. Phylogenetic analysis, overview | Ignicoccus hospitalis |
evolution | virtually all archaeal groups as well as the deeply branching bacterial lineages contain the bifunctional D-fructose 1,6-bisphosphate aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity. This enzyme is missing inmost other Bacteria and in Eukaryota. Phylogenetic analysis, overview | Cenarchaeum symbiosum |
additional information | active site structures, overview | Archaea |
additional information | active site structures, overview | Cenarchaeum symbiosum |
physiological function | the enzyme's bifunctionality ensures that heat-labile triosephosphates are quickly removed and trapped in stabie D-fructose 6-phosphate, rendering gluconeogenesis unidirectional | Cenarchaeum symbiosum |
physiological function | the enzyme's bifunctionality ensures that heat-labile triosephosphates are quickly removed and trapped in stable D-fructose 6-phosphate, rendering gluconeogenesis unidirectional | Archaea |
physiological function | the enzyme's bifunctionality ensures that heat-labile triosephosphates are quickly removed and trapped in stable D-fructose 6-phosphate, rendering gluconeogenesis unidirectional | Ignicoccus hospitalis |