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Literature summary for 3.1.3.11 extracted from

  • Heng, S.; Gryncel, K.R.; Kantrowitz, E.R.
    A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase (2009), Bioorg. Med. Chem., 17, 3916-3922.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
2-(2-(phenylamino)thiazol-4-yl)phenol
-
 Sus scrofa
2-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenol
-
 Sus scrofa
2-(4-phenylthiazol-2-ylamino)phenol
-
 Sus scrofa
3-(4-(4-hydroxyphenyl)thiazol-2-ylamino)benzenesulfonamide
-
 Sus scrofa
3-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenol
-
 Sus scrofa
3-(4-phenylthiazol-2-ylamino)benzenesulfonamide
-
 Sus scrofa
3-(4-phenylthiazol-2-ylamino)phenol
-
 Sus scrofa
4-(2-(2-hydroxyphenylamino)thiazol-4-yl)benzene-1,3-diol
-
 Sus scrofa
4-(2-(3-hydroxyphenylamino)thiazol-4-yl)benzene-1,3-diol
-
 Sus scrofa
4-(2-(3-nitrophenylamino)thiazol-4-yl)phenol
-
 Sus scrofa
4-(2-(4-hydroxyphenylamino)thiazol-4-yl)benzene-1,3-diol
-
 Sus scrofa
4-(2-(4-nitrophenylamino)thiazol-4-yl)phenol
-
 Sus scrofa
4-(2-(phenylamino)thiazol-4-yl)benzene-1,3-diol
-
 Sus scrofa
4-(4-(2,4-dihydroxyphenyl)thiazol-2-ylamino)benzenesulfonamide
-
 Sus scrofa
4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)benzenesulfonamide
-
 Sus scrofa
4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenol
-
 Sus scrofa
4-(4-phenylthiazol-2-ylamino)benzenesulfonamide
-
 Sus scrofa
4-(4-phenylthiazol-2-ylamino)phenol
-
 Sus scrofa
N,4-diphenylthiazol-2-amine
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P00636
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Sus scrofa D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
FBPase
-
 Sus scrofa
fructose 1,6-bisphosphatase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.006
-
-
 Sus scrofa 4-(2-(3-hydroxyphenylamino)thiazol-4-yl)benzene-1,3-diol
0.011
-
-
 Sus scrofa 4-(2-(4-hydroxyphenylamino)thiazol-4-yl)benzene-1,3-diol
0.013
-
-
 Sus scrofa 3-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenol
0.015
-
-
 Sus scrofa 2-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenol
0.02
-
-
 Sus scrofa 4-(2-(2-hydroxyphenylamino)thiazol-4-yl)benzene-1,3-diol
0.032
-
-
 Sus scrofa 4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)benzenesulfonamide
0.035
-
-
 Sus scrofa 3-(4-phenylthiazol-2-ylamino)phenol
0.048
-
-
 Sus scrofa 4-(4-(4-hydroxyphenyl)thiazol-2-ylamino)phenol
0.048
-
-
 Sus scrofa 4-(2-(3-nitrophenylamino)thiazol-4-yl)phenol
0.05
-
-
 Sus scrofa 3-(4-(4-hydroxyphenyl)thiazol-2-ylamino)benzenesulfonamide
0.055
-
-
 Sus scrofa 4-(4-(2,4-dihydroxyphenyl)thiazol-2-ylamino)benzenesulfonamide
0.104
-
-
 Sus scrofa 3-(4-phenylthiazol-2-ylamino)benzenesulfonamide
0.119
-
-
 Sus scrofa 2-(2-(phenylamino)thiazol-4-yl)phenol
0.124
-
-
 Sus scrofa 4-(4-phenylthiazol-2-ylamino)phenol
0.145
-
-
 Sus scrofa 4-(4-phenylthiazol-2-ylamino)benzenesulfonamide
0.246
-
-
 Sus scrofa 4-(2-(4-nitrophenylamino)thiazol-4-yl)phenol
0.27
-
-
 Sus scrofa 2-(4-phenylthiazol-2-ylamino)phenol
0.318
-
-
 Sus scrofa N,4-diphenylthiazol-2-amine
0.343
-
-
 Sus scrofa 4-(2-(phenylamino)thiazol-4-yl)benzene-1,3-diol
2.5
-
-
 Sus scrofa N,4-diphenylthiazol-2-amine