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Literature summary for 3.1.3.11 extracted from

  • Yoshida, T.; Okuno, A.; Izumi, M.; Takahashi, K.; Hagisawa, Y.; Ohsumi, J.; Fujiwara, T.
    CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats (2008), Eur. J. Pharmacol., 601, 192-197.
    View publication on PubMed

Application

Application Comment Organism
medicine CS-917 as an FBPase inhibitor corrects postprandial hyperglycemia as well as fasting hyperglycemia Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
L-alanine, N,N'-[[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl] phosphinylidene]bis-, diethyl ester effect of gluconeogenesis inhibition on postprandial hyperglycemia is investigated using the inhibitor CS-917 in meal-loaded diabetic Goto-Kakizaki rats. CS-917 suppresses plasma glucose elevation after meal loading in a dose-dependent manner at doses ranging from 10 to 40 mg/kg. In an overnight-fasted state, CS-917 decreases the plasma glucose levels dose-dependently at doses ranging from 2.5 to 40 mg/kg. Glucose-lowering is associated with an accumulation of hepatic D-fructose 1,6-bisphosphate and a reduction in hepatic D-fructose 6-phosphate. Chronic treatment of CS-917 decreases plasma glucose significantly, and no significant increase in plasma lactate and no profound elevation in plasma triglycerides are observed by both acute and chronic treatment of CS-917 in Goto-Kakizaki rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Synonyms

Synonyms Comment Organism
FBPase
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Rattus norvegicus
fructose 1,6-bisphosphatase
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Rattus norvegicus