Literature summary for 3.1.3.11 extracted from

Visinoni, S.; Fam, B.C.; Blair, A.; Rantzau, C.; Lamont, B.J.; Bouwman, R.; Watt, M.J.; Proietto, J.; Favaloro, J.M.; Andrikopoulos, S.
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver (2008), Am. J. Physiol. Endocrinol. Metab., 295, E1132-E1141.

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Application

Application	Comment	Organism
medicine	FBPase regulates endogenous glucose production and whole body glucose homeostasis in a liver-specific transgenic model. Transgenic mouse can serve as a model for testing human FBPase inhibitor compounds with the potential to treat patients with type 2 diabetes	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	to determine the role of upregulated liver FBPase in glucose homeostasis human liver FBPase transgenic mice under the control of the transthyretin promoter are generated, expressing the transgene specifically in liver. Hemizygous transgenic mice have an approximately 3fold increase in total liver FBPase mRNA with concomitant increases in FBPase protein and enzyme activity levels. After high-fat feeding, hemizygous transgenics are glucose intolerant compared to wild-type. Homozygous chow-fed transgenic mice show a 5.5fold increase in liver FBPase levels and are glucose intolerant with a significantly higher rate of endogenous glucose production	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
FBPase	-	Homo sapiens
fructose 1,6-bisphosphatase	-	Homo sapiens

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Release 2023.1 (January 2023)