Literature summary for 3.1.3.11 extracted from

Erion, M.D.; Dang, Q.; Reddy, M.R.; Kasibhatla, S.R.; Huang, J.; Lipscomb, W.N.; van Poelje, P.D.
Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity (2007), J. Am. Chem. Soc., 129, 15480-15490.

Search for more literature for 3.1.3.11

Application

Application	Comment	Organism
medicine	AMP site of FBPase may represent a potential drug target for reducing the excessive glucose produced by the gluconeogenesis pathway in patients with type 2 diabetes	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
AMP	-	Homo sapiens
[2-[(6-amino-8,9-dihydro-7H-purin-8-yl)amino]ethyl]phosphonate	-	Homo sapiens
[2-[[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]amino]ethyl]phosphonate	-	Homo sapiens
[3-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]propyl]phosphonate	-	Homo sapiens
[5-(4-amino-1-tert-butyl-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate	-	Homo sapiens
[5-(4-amino-1-tert-butyl-7-ethyl-5-fluoro-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate	-	Homo sapiens
[5-(6-amino-9-tert-butyl-8,9-dihydro-7H-purin-8-yl)-2-furyl]phosphonate	-	Homo sapiens
[5-[6-amino-9-(2,2-dimethylpropyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate	-	Homo sapiens
[5-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate	-	Homo sapiens
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09467	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00009	-	-	Homo sapiens	[5-(4-amino-1-tert-butyl-7-ethyl-5-fluoro-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
0.0011	-	-	Homo sapiens	[5-[6-amino-9-(2,2-dimethylpropyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
0.0012	-	-	Homo sapiens	[5-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
0.0016	-	-	Homo sapiens	[5-(4-amino-1-tert-butyl-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
0.0022	-	-	Homo sapiens	[5-(6-amino-9-tert-butyl-8,9-dihydro-7H-purin-8-yl)-2-furyl]phosphonate
0.005	-	-	Homo sapiens	[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
0.015	-	-	Homo sapiens	[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
0.026	-	-	Homo sapiens	[3-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]propyl]phosphonate
0.097	-	-	Homo sapiens	[2-[[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]amino]ethyl]phosphonate
0.5	-	-	Homo sapiens	[2-[(6-amino-8,9-dihydro-7H-purin-8-yl)amino]ethyl]phosphonate

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)