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Literature summary for 3.1.3.11 extracted from
- Kinetic properties of pig (Sus scrofa domestica) and bovine (Bos taurus) D-fructose-1,6-bisphosphate 1-phosphohydrolase (F1,6BPase): liver-like isozymes in mammalian lung tissue (2000), Comp. Biochem. Physiol. B, 127, 123-134.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Bos taurus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Bos taurus | |
| AMP | - |
Sus scrofa domesticus | |
| D-fructose-2,6-bisphosphate | - |
Bos taurus | |
| D-fructose-2,6-bisphosphate | - |
Sus scrofa domesticus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Sus scrofa domesticus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-bisphosphate + H2O | Bos taurus | enzyme is usually regarded as a regulatory enzyme of gluconeogenesis | D-fructose 6-phosphate + phosphate | - |
? | |
| D-fructose 1,6-bisphosphate + H2O | Sus scrofa domesticus | enzyme is usually regarded as a regulatory enzyme of gluconeogenesis | D-fructose 6-phosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
rabbit | - |
| Sus scrofa domesticus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
- |
Sus scrofa domesticus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Bos taurus | - |
| liver | - |
Sus scrofa domesticus | - |
| lung | - |
Bos taurus | - |
| lung | - |
Sus scrofa domesticus | - |
| muscle | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 17 | - |
lung tissue | Sus scrofa domesticus |
| 19 | - |
lung tissue | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-bisphosphate + H2O | - |
Bos taurus | D-fructose 6-phosphate + phosphate | - |
? | |
| D-fructose 1,6-bisphosphate + H2O | - |
Sus scrofa domesticus | D-fructose 6-phosphate + phosphate | - |
? | |
| D-fructose 1,6-bisphosphate + H2O | enzyme is usually regarded as a regulatory enzyme of gluconeogenesis | Bos taurus | D-fructose 6-phosphate + phosphate | - |
? | |
| D-fructose 1,6-bisphosphate + H2O | enzyme is usually regarded as a regulatory enzyme of gluconeogenesis | Sus scrofa domesticus | D-fructose 6-phosphate + phosphate | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.55 | - |
D-fructose 1,6-bisphosphate | pH 7.5, lung | Bos taurus | |
| 14.8 | - |
D-fructose 1,6-bisphosphate | pH 7.5, lung | Bos taurus | |
| 16.1 | - |
D-fructose 1,6-bisphosphate | pH 7.5, lung | Sus scrofa domesticus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00007 | - |
D-fructose-2,6-bisphosphate | pH 7.5, lung enzyme in presence of AMP | Sus scrofa domesticus | |
| 0.00009 | - |
D-fructose-2,6-bisphosphate | pH 7.5, lung enzyme in presence of AMP | Bos taurus | |
| 0.00019 | - |
D-fructose-2,6-bisphosphate | pH 7.5, lung enzyme | Sus scrofa domesticus | |
| 0.00021 | - |
D-fructose-2,6-bisphosphate | pH 7.5, lung | Bos taurus | |
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