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Literature summary for 3.1.3.11 extracted from

  • Adams, A.; Redden, C.; Menahem, S.
    Characterization of human fructose 1,6-bisphosphatase in control and deficient tissues (1990), J. Inherit. Metab. Dis., 13, 829-848.
    View publication on PubMed
Search for more literature for 3.1.3.11

Activating Compound

Activating Compound Comment Organism Structure
citrate activates Homo sapiens
EDTA activation Homo sapiens
His activation Homo sapiens
NH4+ 0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
K+ at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+ Homo sapiens
NH4+ 0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration Homo sapiens
Zn2+ 0.001-0.010 mM has no significant effect, with 0.002-0.0035 mM Zn2+, in absence of EDTA, 50% inhibition, 80% inhibition by 0.01 mM Zn2+ Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 fructose 1,6-diphosphate alkaline isoenzyme Homo sapiens
0.0034
-
 fructose 1,6-diphosphate neutral isoenzyme Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
K+ at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose 1,6-diphosphate + H2O Homo sapiens the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-diphosphate + H2O the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis Homo sapiens ?
-
 ?
D-fructose 1,6-diphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
 half-life of neutral isoenzyme: 710 s, half-life of alkaline isoenzyme: 764 s Homo sapiens