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Literature summary for 3.1.3.11 extracted from
- Fructose-1,6-bisphosphatase from rat liver (1982), Methods Enzymol., 90, 352-357.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | activation | Rattus norvegicus |  |
| fructose 1,6-diphosphate | substrate inhibition | Rattus norvegicus | |
| His | activation | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Rattus norvegicus | |
| Fe2+ | - |
Rattus norvegicus | |
| Fe3+ | - |
Rattus norvegicus | |
| fructose 2,6-diphosphate | - |
Rattus norvegicus | |
| Li+ | - |
Rattus norvegicus | |
| Zn2+ | due to binding to a noncatalytic divalent metal binding site | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activates | Rattus norvegicus | |
| Mg2+ | divalent cation required. Mn2+ or Mg2+ | Rattus norvegicus | |
| Mn2+ | divalent cation required. Mn2+ or Mg2+ | Rattus norvegicus | |
| Na+ | activates | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
x * 42000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | the enzyme can be phosphorylated by the catalytic subunit of cyclic AMP-dependent protein kinase | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 34 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-diphosphate + H2O | - |
Rattus norvegicus | D-fructose 6-phosphate + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 42000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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