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Literature summary for 3.1.3.106 extracted from

  • Samadi, N.; Bekele, R.; Capatos, D.; Venkatraman, G.; Sariahmetoglu, M.; Brindley, D.N.
    Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance (2011), Biochimie, 93, 61-70.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the active site of the enzyme is on the outer surface of plasma membranes, or the lumenal surface of internal membranes Mus musculus 16020
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidate + H2O
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Mus musculus monoacylglycerol + phosphate
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?

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
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Mus musculus
LPP
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Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of lipid phosphate phosphatases is decreased in many tumors down

General Information

General Information Comment Organism
physiological function the low expression of lipid phosphate phosphatase in many tumor cells makes them hypersensitive to growth promoting and survival signals that are provided by lysophosphatidate, S1P, platelet-derived growth factor and epidermal growth factor. The intracellular actions of the enzyme controls cell migration, division, angiogenesis and chemoresistance. Increased LPP1 expression attenuates lysophosphatidate-induced migration of fibroblasts Mus musculus