Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the active site of the enzyme is on the outer surface of plasma membranes, or the lumenal surface of internal membranes | Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidate + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase | - |
Mus musculus |
LPP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the expression of lipid phosphate phosphatases is decreased in many tumors | down |
General Information | Comment | Organism |
---|---|---|
physiological function | the low expression of lipid phosphate phosphatase in many tumor cells makes them hypersensitive to growth promoting and survival signals that are provided by lysophosphatidate, S1P, platelet-derived growth factor and epidermal growth factor. The intracellular actions of the enzyme controls cell migration, division, angiogenesis and chemoresistance. Increased LPP1 expression attenuates lysophosphatidate-induced migration of fibroblasts | Mus musculus |