Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.102 extracted from

  • Akiyama, T.; Selhub, J.; Rosenberg, J.H.
    FMN phosphatase and FAD pyrophosphatase in rat intestinal brush borders: Role in intestinal absorption of dietary riboflavin (1982), J. Nutr., 112, 263-268.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EDTA 10 mM, 100% inhibition Rattus norvegicus
L-phenylalanine 2.5 mM, 10% inhibition Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine intestinal brush borders Rattus norvegicus
-

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
56
-
30 min, 50% residual activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function inhibition of 14C-riboflavin uptake by FMN and FAD in everted rings of rat intestine is directly related to the amount of conversion of these coenzymes to free riboflavin by intestinal enzymes. When FMN and FAD conversion to riboflavin is inhibited by EDTA, competition with 14C-riboflavin for transport is correspondingly decreased, best explained by a sequential process in which hydrolysis of FMN and FAD by enzymes of the intestinal brush border is followed by absorption of free riboflavin Rattus norvegicus