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Literature summary for 3.1.3.1 extracted from

  • Nam, H.; Sharma, M.; Liu, J.; Hatch, N.
    Tissue nonspecific alkaline phosphatase (TNAP) regulates cranial base growth and synchondrosis maturation (2017), Front. Physiol., 8, 161 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed enzyme-deficient Mus musculus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
ALPL
-
 Homo sapiens
strensiq recombinant enzyme, previously known as asfotase-alfa Homo sapiens
tissue nonspecific alkaline phosphatase
-
 Homo sapiens
TNAP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deficiency diminishes chondrocyte vascular endothelial cell growth factor expression Homo sapiens
physiological function the enzyme influences chondrocyte maturation, apoptosis, and MAPK signaling in a cell autonomous manner. The enzyme is essential for the later stages of endochondral bone development including hypertrophic chondrocyte apoptosis and vascular endothelial cell growth factor-mediated recruitment of blood vessels for replacement of cartilage with bone Homo sapiens