Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.1 extracted from

  • Channar, P.A.; Shah, S.J.; Hassan, S.; Nisa, Z.U.; Lecka, J.; Sevigny, J.; Bajorath, J.; Saeed, A.; Iqbal, J.
    Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5-nucleotidase (2017), Chem. Biol. Drug Des., 89, 365-370 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethylidene)isonicotinohydrazide
-
Bos taurus
(E)-N'-(4'-chlorobenzylidene)isonicotinohydrazide most potent inhibitor for intestinal alkaline phosphatase Bos taurus
(E)-N'-(4-hydroxy-3-methoxybenzylidene)isonicotinohydrazide most potent inhibitor for tissue-non-specific alkaline phosphatase Bos taurus
L-phenylalanine
-
Bos taurus
levamisole
-
Bos taurus
N'-[(Z)-(2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(Z)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(Z)-(4-bromophenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(Z)-(4-fluorophenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(Z)-(4-methoxyphenyl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(Z)-(pyridin-3-yl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus
N'-[(Z)-(pyridin-4-yl)methylidene]pyridine-4-carbohydrazide
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P09487
-
-
Bos taurus P19111
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
IAP
-
Bos taurus
intestinal alkaline phosphatase
-
Bos taurus
tissue-non-specific alkaline phosphatase
-
Bos taurus
TNAP
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00035
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus (E)-N'-(4-hydroxy-3-methoxybenzylidene)isonicotinohydrazide
0.00056
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(4-methoxyphenyl)methylidene]pyridine-4-carbohydrazide
0.00067
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus (E)-N'-(4'-chlorobenzylidene)isonicotinohydrazide
0.00106
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus (E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethylidene)isonicotinohydrazide
0.00144
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(2-hydroxyphenyl)methylidene]pyridine-4-carbohydrazide
0.00146
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(pyridin-3-yl)methylidene]pyridine-4-carbohydrazide
0.00174
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(4-methoxyphenyl)methylidene]pyridine-4-carbohydrazide
0.00182
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide
0.00192
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus (E)-N'-(4-hydroxy-3-methoxybenzylidene)isonicotinohydrazide
0.00226
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(4-fluorophenyl)methylidene]pyridine-4-carbohydrazide
0.00243
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(pyridin-3-yl)methylidene]pyridine-4-carbohydrazide
0.00246
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(pyridin-4-yl)methylidene]pyridine-4-carbohydrazide
0.00398
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus (E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethylidene)isonicotinohydrazide
0.00413
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(4-bromophenyl)methylidene]pyridine-4-carbohydrazide
0.00734
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(3-nitrophenyl)methylidene]pyridine-4-carbohydrazide
0.00972
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(4-bromophenyl)methylidene]pyridine-4-carbohydrazide
0.0175
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus N'-[(Z)-(4-fluorophenyl)methylidene]pyridine-4-carbohydrazide
0.0192
-
tissue-non-specific alkaline phosphatase, pH and temperature not specified in the publication Bos taurus levamisole
0.08
-
intestinal alkaline phosphatase, pH and temperature not specified in the publication Bos taurus L-phenylalanine