Application | Comment | Organism |
---|---|---|
medicine | the control of endogenous inhibitors, such as cysteine, that interfere with the ability of tissue nonspecific alkaline phosphatase to regulate calcium pyrophosphate dihydrate crystal formation and dissolution in joints could be a potential therapeutic option for calcium pyrophosphate dihydrate crystal deposition disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cys | uncompetitive inhibition of phosphatase activity, mixed-competitive inhibition of inorganic pyrophosphatase activity. Inorganic pyrophosphatase activity is inhibited more than phosphatase activity. Ca2+ and Mg2+ ion concentrations may regulate this inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0156 | - |
4-nitrophenyl phosphate | 37°C, pH 7.4, 1 mM Ca2+ | Homo sapiens | |
0.019 | - |
4-nitrophenyl phosphate | 37°C, pH 7.4, with Ca2+ and Mg2+ | Homo sapiens | |
0.027 | - |
4-nitrophenyl phosphate | 37°C, pH 7.4, 1 mM Ca2+, 1 mM Mg2+ | Homo sapiens | |
0.035 | - |
4-nitrophenyl phosphate | 37°C, pH 7.4, 1 mM Mg2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tissue nonspecific alkaline phosphatase | - |
Homo sapiens |
TNAP | - |
Homo sapiens |