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Literature summary for 3.1.26.4 extracted from

  • Ko, C.; Shin, Y.C.; Park, W.J.; Kim, S.; Kim, J.; Ryu, W.S.
    Residues Arg703, Asp777, and Arg781 of the RNase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis (2014), J. Virol., 88, 154-163.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D777A the mutation in the RNase H domain of hepatitis B virus polymerase yields significantly reduced amounts of viral DNAs Minus-strand DNA synthesis is incomplete due to loss of catalytic activity of RNase H Hepatitis B virus
R703A the mutation in the RNase H domain of hepatitis B virus polymerase yields significantly reduced amounts of viral DNAs. Minus-strand DNA synthesis is incomplete due to loss of catalytic activity of RNase H Hepatitis B virus
R781A the mutation in the RNase H domain of hepatitis B virus polymerase yields significantly reduced amounts of viral DNAs. The minus-strand DNA synthesis is near complete to some extent, while the plus-strand DNA synthesis (i.e., relaxed circular DNA) is severely impaired due to the defect in RNase H activity Hepatitis B virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA-DNA hybrid + H2O Hepatitis B virus
-
 ribonucleotide 5'-phosphomonoester + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Hepatitis B virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA-DNA hybrid + H2O
-
 Hepatitis B virus ribonucleotide 5'-phosphomonoester + ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase H
-
 Hepatitis B virus