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Literature summary for 3.1.26.4 extracted from

  • Dirksen, M.L.; Crouch, R.J.
    Selective inhibition of RNase H by dextran (1981), J. Biol. Chem., 256, 11569-11573.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Dextran inhibits degradation of poly(rA)*poly(dT), no inhibition of degradation by phi174DNA-RNA. Dextran does not interfere with the recognition site, but rather blocks hydrolysis Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA-DNA hybrid + H2O phiX174DNA-RNA Escherichia coli ribonucleotide 5'-phosphomonoester
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?
RNA-DNA hybrid + H2O poly(rAdT) Escherichia coli ribonucleotide 5'-phosphomonoester
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?