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Literature summary for 3.1.26.4 extracted from
- Ribonuclease H (1982), Cold Spring Harbor Monogr. Ser., 14, 211-254.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Dextran | - |
Escherichia coli |  |
| Dextran | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| nucleus | - |
Rattus norvegicus | 5634 | - |
| nucleus | large-MW enzyme form | Bos taurus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA-DNA hybrid + H2O | Homo sapiens | - |
? | - |
? | |
| RNA-DNA hybrid + H2O | Escherichia coli | the enzyme could be involved in the removal of RNA primers during DNA replication | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Bos taurus | - |
a large-MW enzyme form and a small-MW enzyme form | - |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Xenopus laevis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Xenopus laevis | - |
| HeLa cell | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| lymphocyte | - |
Bos taurus | - |
| oocyte | - |
Xenopus laevis | - |
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RNA-DNA hybrid + H2O | - |
Mus musculus | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | - |
Homo sapiens | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | - |
Rattus norvegicus | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | - |
Saccharomyces cerevisiae | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | - |
Bos taurus | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | - |
Xenopus laevis | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | hybrid between viral f1 and its complementary RNA, slight preference for cleavage adjacent to pyrimidine | Escherichia coli | ribonucleotide 5'-phosphomonoester | - |
? | |
| RNA-DNA hybrid + H2O | - |
Homo sapiens | ? | - |
? | |
| RNA-DNA hybrid + H2O | the enzyme could be involved in the removal of RNA primers during DNA replication | Escherichia coli | ? | - |
? | |
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