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Literature summary for 3.1.26.3 extracted from

  • Anacker, M.L.; Drecktrah, D.; LeCoultre, R.D.; Lybecker, M.; Samuels, D.S.
    RNase III processing of rRNA in the Lyme disease spirochete Borrelia burgdorferi (2018), J. Bacteriol., 200, e00035-18 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.3

Cloned(Commentary)

Cloned (Comment) Organism
gene rnc, rnc is carried on the chromosome, in a region dense with genes related to translation, two polycistronic transcripts Borreliella burgdorferi

Protein Variants

Protein Variants Comment Organism
additional information generation of an rnc null mutant in Borrelia burgdorferi that exhibits a pleiotropic phenotype, including decreased growth rate and increased cell length. The chromosomal rncBb gene is replaced through homologous recombination with the gentamicin resistance cassette flgBp-aacC1. Mutant rncBb operon structure. The RNase III mutant is viable but has altered processing of rRNA, phenotype, overview Borreliella burgdorferi

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi O51648 strains B31-A3 and 297 (BbAH130)
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cleavage of an artificial 23S rRNA stem-loop substrate by the wild-type enzyme. The sequence is composed of the double-stranded stem portion of the Borrelia burgdorferi 23S rRNA transcript with a loop of four unmatched nucleotides. Modelling for rRNA processing, overview Borreliella burgdorferi ?
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Synonyms

Synonyms Comment Organism
BB_0705
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 Borreliella burgdorferi
endoribonuclease III
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 Borreliella burgdorferi
RNase III
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 Borreliella burgdorferi
rnc
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 Borreliella burgdorferi

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Borreliella burgdorferi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
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 assay at Borreliella burgdorferi

General Information

General Information Comment Organism
malfunction a chromosomal rncBb gene exhibits a pleiotropic phenotype, including decreased growth rate and increased cell length. RNase III mutant is viable but has altered processing of rRNA, phenotype, overview Borreliella burgdorferi
physiological function endoribonuclease III (RNase III) is involved in processing the 23S rRNA in Borrelia burgdorferi. The enzyme is RNase III required for the full maturation of the 23S rRNA but not for the 5S rRNA nor for the 16S rRNA. Several ribonucleases, including RNase III, are involved in the production of ribosomes. RNase III is not essential in Borrelia burgdorferi Borreliella burgdorferi