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Literature summary for 3.1.26.3 extracted from

  • Liang, Y.H.; Lavoie, M.; Comeau, M.A.; Abou Elela, S.; Ji, X.
    Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection (2014), Mol. Cell, 54, 431-444.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of enzyme Rnt1p in complex with a G2 loop Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme Rnt1p binds to RNA stems capped with an NGNN tetraloop, via specific interactions between a structural motif located at the end of the Rnt1p dsRNA-binding domain and the guanine nucleotide in the second position of the loop ?
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?
additional information Saccharomyces cerevisiae ATCC 204508 the enzyme Rnt1p binds to RNA stems capped with an NGNN tetraloop, via specific interactions between a structural motif located at the end of the Rnt1p dsRNA-binding domain and the guanine nucleotide in the second position of the loop ?
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q02555
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Saccharomyces cerevisiae ATCC 204508 Q02555
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme Rnt1p binds to RNA stems capped with an NGNN tetraloop, via specific interactions between a structural motif located at the end of the Rnt1p dsRNA-binding domain and the guanine nucleotide in the second position of the loop Saccharomyces cerevisiae ?
-
?
additional information mode of substrate recognition by the enzyme, which has a unique RNA-binding motif, the enzyme interacts with the RNA stem upstream of the cleavage sites, structure-function analysis, detailed overview. Interaction between the N-terminal domain and RNA increases precision of cleavage site selection Saccharomyces cerevisiae ?
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?
additional information the enzyme Rnt1p binds to RNA stems capped with an NGNN tetraloop, via specific interactions between a structural motif located at the end of the Rnt1p dsRNA-binding domain and the guanine nucleotide in the second position of the loop Saccharomyces cerevisiae ATCC 204508 ?
-
?
additional information mode of substrate recognition by the enzyme, which has a unique RNA-binding motif, the enzyme interacts with the RNA stem upstream of the cleavage sites, structure-function analysis, detailed overview. Interaction between the N-terminal domain and RNA increases precision of cleavage site selection Saccharomyces cerevisiae ATCC 204508 ?
-
?

Synonyms

Synonyms Comment Organism
RNase III
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Saccharomyces cerevisiae
Rnt1p
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
evolution the enzyme is a member of the ribonuclease III (RNase III) family Saccharomyces cerevisiae
additional information the dsRNA-binding domain and N-terminal domains of enzyme Rnt1p function as two rulers that measure the distance between the tetraloop and the cleavage site, mechanism, overview. Both rulers interact with the NGNN tetraloop: ruler 1 recognizes the Gua16 base, and ruler 2 secures the Gua16 recognition Saccharomyces cerevisiae