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Literature summary for 3.1.26.3 extracted from

  • Lee, J.H.; Gatewood, M.L.; Jones, G.H.
    RNase III is required for actinomycin production in Streptomyces antibioticus (2013), Appl. Environ. Microbiol., 79, 6447-6451.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.3

Cloned(Commentary)

Cloned (Comment) Organism
gene rnc, DNA and amino acid sequence determination and analysis, cloning in the overexpression vector pIJ8600 Streptomyces antibioticus

Protein Variants

Protein Variants Comment Organism
additional information generation of a disruption mutant of the chromosomal RNase III gene rnc by insertional mutagenesis, the mutant strain shows reduced actinomycin production. Complementation of mutant strain JSE1980 with pJSE1995 encoding the wild-type rnc gene restores actinomycin production to nearly wild-type levels Streptomyces antibioticus

Organism

Organism UniProt Comment Textmining
Streptomyces antibioticus U3GP13 gene rnc
-
Streptomyces antibioticus IMRU 3720 U3GP13 gene rnc
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Streptomyces antibioticus
-

Synonyms

Synonyms Comment Organism
endoribonuclease III
-
 Streptomyces antibioticus
RNase III
-
 Streptomyces antibioticus

General Information

General Information Comment Organism
evolution the enzyme RNase III is a member of the ubiquitous family of double-strand-specific endoribonucleases. Streptomyces coelicolor and Streptomyces antibioticus are not closely related species within the genus Streptomyces antibioticus
malfunction a gene disruption mutant strain does not produce full-length or truncated forms of RNase III and grows more vigorously than its parent on actinomycin production medium but produces significantly lower levels of actinomycin. Complementation of the rnc disruption with the wild-type rnc gene from Streptomyces antibioticus restores actinomycin production to nearly wild-type levels Streptomyces antibioticus
physiological function the enzyme is required for and regulates antibiotic production Streptomyces antibioticus