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Literature summary for 3.1.26.3 extracted from

  • Viegas, S.C.; Silva, I.J.; Saramago, M.; Domingues, S.; Arraiano, C.M.
    Regulation of the small regulatory RNA MicA by ribonuclease III: a target-dependent pathway (2011), Nucleic Acids Res., 39, 2918-2930.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.3

Activating Compound

Activating Compound Comment Organism Structure
lamB RNA MicA cleavage by RNase III is facilitated by base pairing with MicA mRNA target(s) Salmonella enterica subsp. enterica serovar Typhimurium
ompA RNA MicA cleavage by RNase III is facilitated by base pairing with MicA mRNA target(s) Salmonella enterica subsp. enterica serovar Typhimurium

Cloned(Commentary)

Cloned (Comment) Organism
RNase III in vitro transcription Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Salmonella enterica subsp. enterica serovar Typhimurium in vitro RNase III is active with MicA when it is in complex with its targets, ompA or lamB mRNAs. MicA is cleaved by RNase III in a coupled way with ompA mRNA ?
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 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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 strain SL1344 and derivatives thereof
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in vitro RNase III is active with MicA when it is in complex with its targets, ompA or lamB mRNAs. MicA is cleaved by RNase III in a coupled way with ompA mRNA Salmonella enterica subsp. enterica serovar Typhimurium ?
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 ?
additional information RNase III cleaves dsRNA Salmonella enterica subsp. enterica serovar Typhimurium ?
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 ?

Synonyms

Synonyms Comment Organism
endoribonucleases III
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 Salmonella enterica subsp. enterica serovar Typhimurium
ribonuclease III
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 Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

General Information

General Information Comment Organism
additional information detection of MicA sense transcripts in an RNase III-deficient antisense mutant dependent on ompA Salmonella enterica subsp. enterica serovar Typhimurium
physiological function role of endoribonucleases III and E in Salmonella typhimurium sRNA MicA regulation, MicA is a trans-encoded small non-coding RNA, which downregulates porin-expression in stationaryphase. RNase III regulates MicA in a target-coupled way, while RNase E controls free MicA levels in the cell, mechanisms, overview. ompA expression is regulated by RNase III and is dependent on MicA, and degradation of both the sRNA MicA and the ompA target mRNA is dependent on RNase III Salmonella enterica subsp. enterica serovar Typhimurium