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Literature summary for 3.1.26.3 extracted from
- RNase III cleavage is obligate for maturation but not for function of Escherichia coli pre-23S rRNA (1984), Proc. Natl. Acad. Sci. USA, 81, 185-188.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| double-stranded RNA + H2O | Escherichia coli | cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA | 5'-phosphooligonucleotides | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
mutant strains AB301,105, TS241 RNase III deficient | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| double-stranded RNA + H2O | - |
Escherichia coli | 5'-phosphooligonucleotides | - |
? | |
| double-stranded RNA + H2O | cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA | Escherichia coli | 5'-phosphooligonucleotides | - |
? | |
| ribosomal RNA + H2O | no activity on 23S RNA and 16S RNA | Escherichia coli | smaller precursor rRNA | - |
? | |
| ribosomal RNA + H2O | initiates maturation of 23S and 16S RNA species | Escherichia coli | smaller precursor rRNA | - |
? | |
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Release 2023.1 (January 2023)
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