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Literature summary for 3.1.26.3 extracted from

  • Nicholson, A.W.; Niebling, K.R.; McOsker, P.L.; Robertson, H.D.
    Accurate in vitro cleavage by RNase III of phosphorothioate-substituted RNA processing signals in bacteriophage T7 early mRNA (1988), Nucleic Acids Res., 16, 1577-1591.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
double-stranded RNA + H2O Escherichia coli cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA 5'-phosphooligonucleotides
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
double-stranded RNA + H2O
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 Escherichia coli 5'-phosphooligonucleotides
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 ?
double-stranded RNA + H2O cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA Escherichia coli 5'-phosphooligonucleotides
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RNA substituted with guanosine 5'-O-(1-thiotriphosphate) + H2O cleavage specificity is not altered by modified RNA Escherichia coli 5'-phosphooligonucleotides containing guanosine 5'-O-(1-thiotriphosphate)
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