Literature summary for 3.1.26.3 extracted from

Chen, S.M.; Takiff, H.E.; Barber, A.M.; Dubois, G.C.; Bardwell, J.C.A.; Court, D.L.
Expression and characterization of RNase III and Era proteins. Products of the rnc operon of Escherichia coli (1990), J. Biol. Chem., 265, 2888-2895.

Search for more literature for 3.1.26.3

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of the rnc gene in Escherichia coli	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
double-stranded RNA + H2O	Escherichia coli	cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA	5'-phosphooligonucleotides	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
of the overexpressed protein	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
double-stranded RNA + H2O	-	Escherichia coli	5'-phosphooligonucleotides	-	?
double-stranded RNA + H2O	cleaves multimeric tRNA precursor at the spacer region, also involved in processing of precursor rRNA, hnRNA and early T7-mRNA. Also cleaves double-stranded DNA and single-stranded RNA	Escherichia coli	5'-phosphooligonucleotides	-	?
mRNA transcripts + H2O	reduces expression of itself	Escherichia coli	5'-phosphooligonucleotides	-	?
mRNA transcripts + H2O	to affect gene expression	Escherichia coli	5'-phosphooligonucleotides	-	?
ribosomal RNA + H2O	no activity on 23S RNA and 16S RNA	Escherichia coli	smaller precursor rRNA	-	?
ribosomal RNA + H2O	initiates maturation of 23S and 16S RNA species	Escherichia coli	smaller precursor rRNA	-	?

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Release 2023.1 (January 2023)