Literature summary for 3.1.26.13 extracted from

Ngcapu, S.; Theys, K.; Libin, P.; Marconi, V.C.; Sunpath, H.; Ndungu, T.; Gordon, M.L.
Characterization of nucleoside reverse transcriptase inhibitor-associated mutations in the RNase H region of HIV-1 subtype C infected individuals (2017), Viruses, 9, 330-339 .

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Cloned(Commentary)

Cloned (Comment)	Organism
the entire RNase H region of reverse transcriptase RT is encoded in codons 431-560, DNA and amino acid sequence determination and analysis, genotyping	Human immunodeficiency virus type 1 subtype C

Protein Variants

Protein Variants	Comment	Organism
A554S	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
D460N	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
D488E	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
D549N	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
E529D	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
H539N	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
I505A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
I506L	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K451R	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K476A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K476N	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K512Q	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K527N	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K530R	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K558E	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
K558R	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
L469F	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
L491S	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
additional information	characterization of nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations in the RNase H region of HIV-1 subtype C infected individuals, overview. Mutations are identified by comparing with NRTI-associated RNase H mutations previously identified from subtype B drug-resistance studies	Human immunodeficiency virus type 1 subtype C
N474A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
Q475A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
Q500A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
Q509L	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
Q547K	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
T470N	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
T473A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
V518I	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
Y501A	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C
Y501F	naturally occurring mutation in the RNase H region of HIV-1 subtype C infected individual	Human immunodeficiency virus type 1 subtype C

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus type 1 subtype C	-	HIV-1	-

Synonyms

Synonyms	Comment	Organism
RNase H	-	Human immunodeficiency virus type 1 subtype C
RNase H of HIV-1 subtype C	-	Human immunodeficiency virus type 1 subtype C

General Information

General Information	Comment	Organism
malfunction	identification of nucleoside reverse transcriptase inhibitor (NRTI) treatment-related mutations in RNase H of HIV-1 subtype C, overview	Human immunodeficiency virus type 1 subtype C