Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.26.13 extracted from

  • Himmel, D.M.; Myshakina, N.S.; Ilina, T.; Van Ry, A.; Ho, W.C.; Parniak, M.A.; Arnold, E.
    Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs (2014), J. Mol. Biol., 426, 2617-2631.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.13

Inhibitors

Inhibitors Comment Organism Structure
F3284-8495 specific inhibitor with low micromolar potency in vitro Human immunodeficiency virus 1
F3385-2581
-
 Human immunodeficiency virus 1
F3385-2588
-
 Human immunodeficiency virus 1
F3385-2590
-
 Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Synonyms

Synonyms Comment Organism
reverse transcriptase
-
 Human immunodeficiency virus 1
reverse transcriptase-associated ribonuclease H
-
 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 1

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0004
-
 10 mM Mg2+, at pH 8.0 and 37°C Human immunodeficiency virus 1 F3385-2590
0.0007
-
 10 mM Mg2+, at pH 8.0 and 37°C Human immunodeficiency virus 1 F3385-2588
0.0008
-
 1 mM Mg2+, at pH 7.4 and 37°C Human immunodeficiency virus 1 F3385-2590
0.0011
-
 10 mM Mg2+, at pH 8.0 and 37°C Human immunodeficiency virus 1 F3284-8495
0.0019
-
 10 mM Mg2+, at pH 8.0 and 37°C Human immunodeficiency virus 1 F3385-2581
0.0021
-
 1 mM Mg2+, at pH 7.4 and 37°C Human immunodeficiency virus 1 F3385-2588
0.0022
-
 1 mM Mg2+, at pH 7.4 and 37°C Human immunodeficiency virus 1 F3385-2581
0.0048
-
 1 mM Mg2+, at pH 7.4 and 37°C Human immunodeficiency virus 1 F3284-8495