Protein Variants | Comment | Organism |
---|---|---|
A128T | the mutant strain is resistant to 2-hydroxyisoquinoline-1,3(2H,4H)-dione inhibitors in contrast to the wild-type | Moloney murine leukemia virus |
G140S/Q148H | the mutant strain is resistant to 2-hydroxyisoquinoline-1,3(2H,4H)-dione inhibitors in contrast to the wild-type | Moloney murine leukemia virus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H,4H)-dione | shows antiviral activity | Moloney murine leukemia virus | |
2-hydroxy-4-methylisoquinoline-1,3(2H,4H)-dione | - |
Moloney murine leukemia virus | |
2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Moloney murine leukemia virus | |
2-hydroxyisoquinoline-1,3(2H,4H)-dione magnesium complex | - |
Moloney murine leukemia virus | |
beta-thujaplicinol | - |
Moloney murine leukemia virus | |
diketoacid | - |
Moloney murine leukemia virus | |
L-708,906 | - |
Moloney murine leukemia virus | |
L-870,810 | - |
Moloney murine leukemia virus | |
additional information | magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain, overview. 2-Hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+, but a 1:2 complex with Mn2+, | Moloney murine leukemia virus | |
raltegravir | - |
Moloney murine leukemia virus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Moloney murine leukemia virus | |
additional information | the active site of the RNase H function contains four acidic residues, D443, E478, D498, and D549, that likely coordinate two divalent metal ions that are essential for catalysis | Moloney murine leukemia virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Moloney murine leukemia virus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Moloney murine leukemia virus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the active site of the RNase H function contains four acidic residues, D443, E478, D498, and D549, that likely coordinate two divalent metal ions that are essential for catalysis | Moloney murine leukemia virus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNase H | - |
Moloney murine leukemia virus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Moloney murine leukemia virus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Moloney murine leukemia virus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000061 | - |
pH 8.0, 37°C | Moloney murine leukemia virus | 2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H,4H)-dione | |
0.0301 | - |
pH 8.0, 37°C | Moloney murine leukemia virus | 2-hydroxyisoquinoline-1,3(2H,4H)-dione magnesium complex | |
0.0388 | - |
pH 8.0, 37°C | Moloney murine leukemia virus | 2-hydroxy-4-methylisoquinoline-1,3(2H,4H)-dione | |
0.0591 | - |
pH 8.0, 37°C | Moloney murine leukemia virus | 2-hydroxyisoquinoline-1,3(2H,4H)-dione |
General Information | Comment | Organism |
---|---|---|
malfunction | antiviral activity of 2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H,4H)-dione is probably due to the RNase H inhibition | Moloney murine leukemia virus |