Literature summary for 3.1.26.13 extracted from

Brincat, J.L.; Pfeiffer, J.K.; Telesnitsky, A.
RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication (2002), J. Virol., 76, 88-95.

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Protein Variants

Protein Variants	Comment	Organism
D524N	loss of catalytic activity. Construction of vectors encapsidated in virions engineered to contain phenotypic mixtures of wild-type and RNase H catalytic site point mutant D524N reverse transcriptase. There is a steady decline in direct repeat deletion frequency that correlates with decreases in functional RNase H, with greater than fourfold decreases in repeat deletion frequency observed when 95% of virion reverse transcriptase is RNase H defective	Moloney murine leukemia virus

Organism

Organism	UniProt	Comment	Textmining
Moloney murine leukemia virus	-	-	-

General Information

General Information	Comment	Organism
physiological function	increasing the stoichiometry of RNase H relative to the amount of functional DNA polymerase by virions engineered to contain phenotypic mixtures of wild-type and RNase H catalytic site point mutant D524N reverse transcriptase, has minimal effects on direct repeat deletion frequency. DNA synthesis is error prone when directed principally by RNase H mutant reverse transcriptase, suggesting a role for RNase H catalytic integrity in the fidelity of intracellular reverse transcription	Moloney murine leukemia virus

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Release 2023.1 (January 2023)