Protein Variants | Comment | Organism |
---|---|---|
D549A | mutation in polypeptide p66, decrease in RNase H activity | Human Immunodeficiency Virus |
D549N | mutation in polypeptide p66, decrease in RNase H activity | Human Immunodeficiency Virus |
E478Q | mutation in polypeptide p66, loss of RNase H activity | Human Immunodeficiency Virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human Immunodeficiency Virus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | evaluation of activity by enzyme's ability to select and extend the 3' polypurine tract primers into (+) strand DNA. Evaluation via concerted and two-step reactions for (+) strand priming, the latter of which allows discrimination between selection end extension events | Human Immunodeficiency Virus | ? | 3' polypurine tract primer selection appears to represent a specialized form of RNase H activity that is more sensitive to minor structural alterations within this domain | ? |