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Literature summary for 3.1.26.13 extracted from

  • Allen, S.; Krawczyk, S.; McGee, L.; Bischofberger, N.; Mulato, A.; Cherrington, J.
    Inhibition of HIV-1 RNase H activity by nucleotide dimers and monomers (1996), Antiviral Chem. Chemother., 7, 37-45.
No PubMed abstract available
Search for more literature for 3.1.26.13

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-guanosine 40% inhibition of RNase H at 0.05 microM Human immunodeficiency virus 1
2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-naphthalen-1-ylguanosine 61% inhibition of RNase H at 0.05 microM Human immunodeficiency virus 1
2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-naphthalen-1-ylguanosine 11% inhibition of RNase H at 0.05 microM Moloney murine leukemia virus
2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-[2-(4-nitrophenyl)ethyl]guanosine 69% inhibition of RNase H at 0.05 microM Human immunodeficiency virus 1
2'-deoxy-P-thioguanylyl-(3'->5')-guanosine 65% inhibition of RNase H at 0.05 microM Human immunodeficiency virus 1
guanylyl-(3'->5')-guanosine 89% inhibition of RNase H at 0.05 microM Human immunodeficiency virus 1
P-thioguanylyl-(3'->5')-guanosine 50% inhibition of RNase H at 0.05 microM Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-
Moloney murine leukemia virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(rG)/poly(dC) + H2O
-
 Moloney murine leukemia virus ?
-
 ?
poly(rG)/poly(dC) + H2O
-
 Human immunodeficiency virus 1 ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0115
-
 2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-[2-(4-nitrophenyl)ethyl]guanosine
-
 Human immunodeficiency virus 1

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.04
-
-
 Human immunodeficiency virus 1 2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-naphthalen-1-ylguanosine
0.04
-
-
 Human immunodeficiency virus 1 2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-[2-(4-nitrophenyl)ethyl]guanosine