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Literature summary for 3.1.26.12 extracted from

  • Afonyushkin, T.; Vecerek, B.; Moll, I.; Blasi, U.; Kaberdin, V.R.
    Both RNase E and RNase III control the stability of sodB mRNA upon translational inhibition by the small regulatory RNA RyhB (2005), Nucleic Acids Res., 33, 1678-1689.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
chaperone Hfq plays an important role in facilitating the interaction ofRyhB with sodB mRNA, Hfq is not tightly retained by the RyhB-sodB mRNA complex and can be released from it through interaction with other RNAs added in trans Escherichia coli
Hfq a factor binding to the sodB RNA and facilitating cleavage due to induced conformational changes within the 5'-UTR, overview Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Escherichia coli
Mg2+ required Escherichia coli
NH4Cl
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli both RNase E and RNase III control the stability of sodB mRNA upon translational inhibition by the small regulatory RNA RyhB, iron-dependent variations in the steady-state concentration and translatability of sodB mRNA are modulated by the small regulatory RNA RyhB, the RNA chaperone Hfq, and RNase E, decay of sodB mRNA is retarded upon inactivation of RNaseE in vivo, mechanism, modelling, overview ?
-
 ?
sodB mRNA + H2O Escherichia coli RNase E and RNase III are required for sodB RNA decay in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 several strains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
endonulceolytic cleavage of sodB mRNA the enzyme cleaves within the sodB 5'-untranslated region in vitro, thereby removing the 5' stem-loop structure that facilitates Hfq and ribosome binding, RNase E cleavage can also occur at a cryptic site that becomes available upon sodB 5'-UTR/RyhB base pairing Escherichia coli ?
-
 ?
additional information both RNase E and RNase III control the stability of sodB mRNA upon translational inhibition by the small regulatory RNA RyhB, iron-dependent variations in the steady-state concentration and translatability of sodB mRNA are modulated by the small regulatory RNA RyhB, the RNA chaperone Hfq, and RNase E, decay of sodB mRNA is retarded upon inactivation of RNaseE in vivo, mechanism, modelling, overview Escherichia coli ?
-
 ?
sodB mRNA + H2O RNase E and RNase III are required for sodB RNA decay in vivo Escherichia coli ?
-
 ?
sodB192 mRNA + H2O cleavage of the 5'-untranslated region in vitro thereby removing the stem loop structure that facilitates Hfq and ribosome binding, additional cleavage at a cryptic site, that becomes available upon sodB5'-UTR/RyhB base pairing, RyhB is a small regulatory RNA involved in sodB translation control, overview Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase E
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Escherichia coli