Literature summary for 3.1.26.11 extracted from

Shang, J.; Wu, L.; Yang, Y.; Li, Y.; Liu, Z.; Huang, Y.
Overexpression of Schizosaccharomyces pombe tRNA 3-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death (2019), Fungal Genet. Biol., 122, 11-20 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Schizosaccharomyces pombe	P87168	-	-
Schizosaccharomyces pombe ATCC 24843	P87168	-	-

Synonyms

Synonyms	Comment	Organism
TRZ2	-	Schizosaccharomyces pombe

General Information

General Information	Comment	Organism
metabolism	trz2 overexpression is toxic to cells. It leads to apoptotic cell death. Overexpression of trz2 also caused a loss of mitochondrial membrane potential and an increased reactive oxygen species formation. Overexpressing trz2 increases the level of intracellular iron by about 2fold. trz2 overexpression may cause mitochondrial dysfunction, which is likely to lead to perturbation of iron homeostasis, ROS accumulation and induction of apoptotic cell death in Schizosaccharomyces pombe	Schizosaccharomyces pombe
physiological function	the enzyme is involved in nuclear and mitochondrial tRNA 3'-end processing	Schizosaccharomyces pombe

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Release 2023.1 (January 2023)