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Literature summary for 3.1.21.7 extracted from

  • Fladeby, C.; Vik, E.S.; Laerdahl, J.K.; Gran Neurauter, C.; Heggelund, J.E.; Thorgaard, E.; Strom-Andersen, P.; Bjoras, M.; Dalhus, B.; Alseth, I.
    The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures (2012), PLoS ONE, 7, e47466.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.21.7

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-Codon Plus (DE3)-RIPL cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y91A the mutant has lost its affinity for branched DNA substrates Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleolus
-
 Homo sapiens 5730
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme shows affinity for but does not cleave branched DNA substrates like 5'-flap, 3'-flap, pseudo-Y, fork, 3-way junction, and Holliday junction ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N8Q3
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex 75 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
prostate gland
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-
testis highest expression Homo sapiens
-
urinary bladder
-
 Homo sapiens
-
uterine cervix
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows affinity for but does not cleave branched DNA substrates like 5'-flap, 3'-flap, pseudo-Y, fork, 3-way junction, and Holliday junction Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
endonuclease V
-
 Homo sapiens
EndoV
-
 Homo sapiens