Literature summary for 3.1.21.7 extracted from

Kanugula, S.; Pauly, G.T.; Moschel, R.C.; Pegg, A.E.
A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities (2005), Proc. Natl. Acad. Sci. USA, 102, 3617-3622.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli GWR109	Ferroplasma acidarmanus

Organism

Organism	UniProt	Comment	Textmining
Ferroplasma acidarmanus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant	Ferroplasma acidarmanus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA + H2O	the recombinant protein repais O6-methylguanine lesions in DNA via alkyl transfer action. The AGTendoV recombinant protein also cleaves DNA substrates that contain the deaminated bases uracil, hypoxanthine, or xanthine in a similar manner to Escherichia coli endonuclease V	Ferroplasma acidarmanus	?	-	?

Synonyms

Synonyms	Comment	Organism
AGTendoV	bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities	Ferroplasma acidarmanus

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Release 2023.1 (January 2023)