Crystallization (Comment) | Organism |
---|---|
in complex with magnesium and phosphate ions, both bound in the active site, to 1.95 A resolution. Data suggest a magnesium-assisted pentavalent phosphate transition state during catalysis, where Asp168 may play a key role as a general catalytic base. Residue Asn7 plays a critical role in the catalytic mechanism, participating indirectly in the coordination sphere of the Mg2+ ion with an H-bond of its amide oxygen with a coordinated water molecule and connects Asp168 and Glu39 with an H-bonding network via its amide nitrogen | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N7A | complete loss of activity | Homo sapiens |
N7S | complete loss of activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P24855 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
deoxyribonuclease-1 | - |
Homo sapiens |
Dnase1 | - |
Homo sapiens |