Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.21.1 extracted from

  • Takeshita, H.; Soejima, M.; Koda, Y.; Yasuda, T.; Takatsuka, H.; Fujihara, J.
    Gln222Arg (A2317G) polymorphism in the deoxyribonuclease I gene exhibits ethnic and functional differences (2009), Clin. Chem. Lab. Med., 47, 51-55.
    View publication on PubMed
Search for more literature for 3.1.21.1

Application

Application Comment Organism
medicine single nucleotide polymorphism in exon 8, is associated with several diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNase I cDNA, derived from genes DNASE1-1 and DNASE1-2 ligated into a pcDNA3.1 (+) vector and expressed in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q222R single nucleotide polymorphism in exon 8, is associated with several diseases. Gene DNASE1-1 is more common in Africans and gene DNASE1-2 is more common in Caucasians. Optimum pH for the DNase I type-1 enzyme is 6.75, while that for the type-2 enzyme is 6.5. Activity of the DNase I type-2 enzyme is 1.33times higher than that of the type-1 enzyme. The type-1 enzyme is heat labile when compared to the type-2 enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas from homozygote subjects Homo sapiens
-

Synonyms

Synonyms Comment Organism
deoxyribonuclease I
-
 Homo sapiens
DNase I
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 DNase I type-2 enzyme Homo sapiens
6.75
-
 DNase I type-1 enzyme Homo sapiens