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Literature summary for 3.1.21.1 extracted from
- Shedding of sulfated lipids into gastric fluid and inhibition of pancreatic DNase I by cholesterol sulfate in concert with bile acids (2000), Biochim. Biophys. Acta, 1487, 268-274.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Bile acids | inhibit the enzyme in concert with cholesterol sulfate | Bos taurus |  |
| Cholesterol sulfate | from human gastric fluid, the sulfate group and the hydrophobic side chain of cholesterol sulfate are indispensable for the inhibitory effect, irreversible, dependent on bile acids, a ratio of 342:1 of bile acids to cholesterol sulfate is required for complete inhibition | Bos taurus | |
| additional information | no inhibition by sulfatides and membrane lipids, galactose ceramide, no inhibition by steroid sulfates such as estrone sulfate, pregnenolone sulfate, dehydroepiandrosterone sulfate, no inhibition by DMSO, Tween 20, sodium cholate, and sodium taurocholate | Bos taurus | |
| SDS | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products | preference for double-stranded DNA | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Bos taurus | - |
| pancreas | - |
Bos taurus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkaline deoxyribonuclease | - |
Bos taurus |
| alkaline DNase | - |
Bos taurus |
| deoxyribonuclease (pancreatic) | - |
Bos taurus |
| deoxyribonuclease A | - |
Bos taurus |
| deoxyribonucleic phosphatase | - |
Bos taurus |
| DNA endonuclease | - |
Bos taurus |
| DNA nuclease | - |
Bos taurus |
| DNA polymerase | - |
Bos taurus |
| DNAase | - |
Bos taurus |
| DNase | - |
Bos taurus |
| DNase I | - |
Bos taurus |
| domase | - |
Bos taurus |
| dornava | - |
Bos taurus |
| dornavac | - |
Bos taurus |
| EC 3.1.4.5 | formerly | Bos taurus |
| endodeoxyribinuclease I | - |
Bos taurus |
| Escherichia coli endonuclease I | - |
Bos taurus |
| pancreatic deoxyribonuclease | - |
Bos taurus |
| pancreatic DNase | - |
Bos taurus |
| pancreatic dornase | - |
Bos taurus |
| thymonuclease | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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