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Literature summary for 3.1.2.6 extracted from

  • Danford, J.J.; Dobrowolski, P.; Berreau, L.M.
    Thioester hydrolysis reactivity of an Fe(III)Zn(II) complex (2009), Inorg. Chem., 48, 11352-11361.
    View publication on PubMed
Search for more literature for 3.1.2.6

Activating Compound

Activating Compound Comment Organism Structure
additional information the Fe(III)Zn(II) complex [(2-{[bis(2-pyridylmethyl)amino]methyl}-6-[{[2-hydroxyphenyl)methyl]-(2-pyridylmethyl)amino}methyl]-4-methylphenolFe(III)Zn(II)(micro-O2C2H3)2]ClO4 promotes thioester hydrolysis Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Fe3+ thioester hydrolysis is promoted by an Fe(III)Zn(II) complex. Thioester does not initially interact with the Fe(III) center, changes occur at this site over the course of the reaction. Formation of a Fe(III)-S-methyl ester moiety, which likely results from redox activity involving an iron(III) thiolate species. Thioester hydrolysis may involve initial coordination of the deprotonated alpha-hydroxy thioester to the zinc center followed by nucleophilic attack by a terminal Fe(III)-OH moiety and thiolate leaving group stabilization by the Fe(III) center Arabidopsis thaliana
Zn2+ thioester hydrolysis is promoted by an Fe(III)Zn(II) complex. Thioester hydrolysis may involve initial coordination of the deprotonated alpha-hydroxy thioester to the zinc center followed by nucleophilic attack by a terminal Fe(III)-OH moiety and thiolate leaving group stabilization by the Fe(III) center Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-methyl hydroxy(phenyl)ethanethioate + H2O thioester hydrolysis is promoted by an Fe(III)Zn(II) complex Arabidopsis thaliana methanethiol + hydroxy(phenyl)acetic acid
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 ?

Synonyms

Synonyms Comment Organism
GlxII
-
 Arabidopsis thaliana
glyoxalase II
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 Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
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 saturation kinetic behavior for the phosphate diester hydrolysis reaction Arabidopsis thaliana

pH Range

pH Minimum pH Maximum Comment Organism
7 9 saturation kinetic behavior for the thioester hydrolysis reaction. At pH 9.0 ligand exchange at the zinc center via deprotonation of the alpha-hydroxy group of the thioester to give an equilibrium amount of a zinc alkoxide species Arabidopsis thaliana