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Literature summary for 3.1.2.6 extracted from

  • Yadav, S.K.; Singla-Pareek, S.L.; Sopory, S.K.
    An overview on the role of methylglyoxal and glyoxalases in plants (2008), Drug Metabol. Drug Interact., 23, 51-68.
    View publication on PubMed
Search for more literature for 3.1.2.6

Activating Compound

Activating Compound Comment Organism Structure
auxin enhances activity of both gly I and II Glycine max
additional information coldnesse enhances gly II transcript expression Brassica sp.
additional information drought enhances gly II transcript expression Brassica sp.
additional information salt enhances gly II transcript expression Brassica sp.
additional information zinc stress enhances gly II transcript expression Brassica sp.

Cloned(Commentary)

Cloned (Comment) Organism
-
 Arabidopsis thaliana
Brassica sp. gly II Brassica sp.

Inhibitors

Inhibitors Comment Organism Structure
N,S-bis-carbobenzoxy-glutathione
-
 Arabidopsis thaliana
N,S-bis-FMOC-glutathione
-
 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Zea mays 5829
-
cytosol
-
 Solanum tuberosum 5829
-
cytosol
-
 Glycine max 5829
-
cytosol
-
 Arabidopsis thaliana 5829
-
cytosol
-
 Brassica sp. 5829
-
membrane associated Zea mays 16020
-
membrane associated Solanum tuberosum 16020
-
membrane associated Glycine max 16020
-
membrane associated Arabidopsis thaliana 16020
-
membrane associated Brassica sp. 16020
-
mitochondrion
-
 Zea mays 5739
-
mitochondrion
-
 Solanum tuberosum 5739
-
mitochondrion
-
 Glycine max 5739
-
mitochondrion
-
 Arabidopsis thaliana 5739
-
mitochondrion
-
 Brassica sp. 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe3+ Arabidopsis thaliana mitochondrial and cytosolic gly II can accomodate a number of different metal centers, enzyme contains an iron-zinc binuclear metal center that os essential for activity Arabidopsis thaliana
Mn2+ no binding to Arabidopsis thaliana mitochondrial enzyme, but binding to cytosolic gly II Arabidopsis thaliana
Zn2+ binding affinity Zea mays
Zn2+ binding affinity Solanum tuberosum
Zn2+ binding affinity Glycine max
Zn2+ binding affinity Arabidopsis thaliana
Zn2+ binding affinity Brassica sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 Zea mays gly II enzyme is a monomer Zea mays

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Zea mays the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes ?
-
 ?
additional information Solanum tuberosum the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes ?
-
 ?
additional information Glycine max the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes ?
-
 ?
additional information Arabidopsis thaliana the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes ?
-
 ?
additional information Brassica sp. the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes ?
-
 ?
S-D-lactoylglutathione + H2O Zea mays second step in the glyoxalase system D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O Solanum tuberosum second step in the glyoxalase system D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O Glycine max second step in the glyoxalase system D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O Arabidopsis thaliana second step in the glyoxalase system D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O Brassica sp. second step in the glyoxalase system D-lactate + glutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Brassica sp.
-
-
-
Glycine max
-
 soybean
-
Solanum tuberosum
-
-
-
Zea mays
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Zea mays
Arabidopsis thaliana gly II Arabidopsis thaliana
Brassica sp. gly II Brassica sp.

Source Tissue

Source Tissue Comment Organism Textmining
flower bud differential expression of mitochondrial and cytosolic gly II Arabidopsis thaliana
-
flower bud differential expression of mitochondrial and cytosolic gly II Brassica sp.
-
leaf gly II Zea mays
-
leaf gly II Arabidopsis thaliana
-
leaf gly II Brassica sp.
-
root differential expression of mitochondrial and cytosolic gly II Zea mays
-
root differential expression of mitochondrial and cytosolic gly II Arabidopsis thaliana
-
root differential expression of mitochondrial and cytosolic gly II Brassica sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes Zea mays ?
-
 ?
additional information the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes Solanum tuberosum ?
-
 ?
additional information the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes Glycine max ?
-
 ?
additional information the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes Arabidopsis thaliana ?
-
 ?
additional information the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes Brassica sp. ?
-
 ?
S-D-lactoylglutathione + H2O second step in the glyoxalase system Zea mays D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O second step in the glyoxalase system Solanum tuberosum D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O second step in the glyoxalase system Glycine max D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O second step in the glyoxalase system Arabidopsis thaliana D-lactate + glutathione
-
 ?
S-D-lactoylglutathione + H2O second step in the glyoxalase system Brassica sp. D-lactate + glutathione
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Zea mays

Synonyms

Synonyms Comment Organism
glyoxalase II
-
 Zea mays
glyoxalase II
-
 Solanum tuberosum
glyoxalase II
-
 Glycine max
glyoxalase II
-
 Arabidopsis thaliana
glyoxalase II
-
 Brassica sp.
hydroxyacylglutathione hydrolase
-
 Zea mays
hydroxyacylglutathione hydrolase
-
 Solanum tuberosum
hydroxyacylglutathione hydrolase
-
 Glycine max
hydroxyacylglutathione hydrolase
-
 Arabidopsis thaliana
hydroxyacylglutathione hydrolase
-
 Brassica sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.89
-
 N,S-bis-FMOC-glutathione
-
 Arabidopsis thaliana
2.3
-
 di-carbobenzoxyglutathione
-
 Arabidopsis thaliana

pI Value

Organism Comment pI Value Maximum pI Value
Zea mays acidic pI of plant gly II ranges from 4.5-6.2
-
 additional information
Solanum tuberosum acidic pI of plant gly II ranges from 4.5-6.2
-
 additional information
Glycine max acidic pI of plant gly II ranges from 4.5-6.2
-
 additional information
Arabidopsis thaliana acidic pI of plant gly II ranges from 4.5-6.2
-
 additional information
Brassica sp. acidic pI of plant gly II ranges from 4.5-6.2
-
 additional information