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Literature summary for 3.1.2.6 extracted from
- Microbial glyoxalase enzymes: metalloenzymes controlling cellular levels of methylglyoxal (2008), Drug Metabol. Drug Interact., 23, 29-50.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Escherichia coli | 5829 | - |
| cytosol | - |
Arabidopsis thaliana | 5829 | - |
| mitochondrion | - |
Arabidopsis thaliana | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | glxII apoenzyme activity is regained | Escherichia coli |  |
| Mn2+ | glxII apoenzyme activity is regained | Escherichia coli | |
| additional information | the cytosolic and mitochondrial glxII from Arabidopsis thaliana contain varying ratios of Zn2+, Fe2+ and Mn2+ and exhibit broad metal activation | Arabidopsis thaliana | |
| Ni2+ | no activity of glxII, re-addition of Zn2+ results in a further inhibition of the residual enzyme activity of the incompletely demetalled apo-GlxII | Escherichia coli | |
| Zn2+ | glxII is a binuclear metalloenzyme with Zn2+ as the probable active site metal ion | Arabidopsis thaliana | |
| Zn2+ | glxII is a binuclear metalloenzyme with Zn2+ as the probable active site metal ion, glxII is isolated with approximately two mol of Zn2+ bound per mole of glxII | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes | ? | - |
? | |
| additional information | Arabidopsis thaliana | the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes | ? | - |
? | |
| S-D-lactoylglutathione + H2O | Escherichia coli | second step in the glyoxalase system, detoxification of methylglyoxal | D-lactate + glutathione | - |
? | |
| S-D-lactoylglutathione + H2O | Arabidopsis thaliana | second step in the glyoxalase system, detoxification of methylglyoxal | D-lactate + glutathione | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes | Escherichia coli | ? | - |
? | |
| additional information | the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes | Arabidopsis thaliana | ? | - |
? | |
| S-D-lactoylglutathione + H2O | second step in the glyoxalase system, detoxification of methylglyoxal | Escherichia coli | D-lactate + glutathione | - |
? | |
| S-D-lactoylglutathione + H2O | second step in the glyoxalase system, detoxification of methylglyoxal | Arabidopsis thaliana | D-lactate + glutathione | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GlxII | - |
Escherichia coli |
| GlxII | - |
Arabidopsis thaliana |
| glyoxalase II | - |
Escherichia coli |
| glyoxalase II | - |
Arabidopsis thaliana |
| hydroxyacylglutathione hydrolase | - |
Escherichia coli |
| hydroxyacylglutathione hydrolase | - |
Arabidopsis thaliana |
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Release 2023.1 (January 2023)
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